[发明专利]急、慢性高原反应易感基因预警检测试剂盒

摘要

本发明公开了一种急、慢性高原反应易感基因预警检测试剂盒，属于基因检测技术领域。本发明采用核酸质谱技术建立一套用于高原反应相关基因检测方法，通过对基因检测结果的分析，利用模型计算高原反应患病风险，可针对高危人群进行高原反应防治知识普及，增加对高原反应重视；对特殊人群进行风险评估，筛选出高风险人群，对高风险人群进行密切关注；结合非遗传因素及家族史数据，尽早警示高原反应高危人群，尽量降低甚至避免高原反应后遗症的发生率及死亡率。本发明具有操作简单、准确率高、高通量、检测成本低等优点。

主权项

1.一种急、慢性高原反应易感基因预警检测试剂盒，其特征在于，包括对rs1801133、rs10193827、rs10206434、rs150877473、rs2275279、rs55981512、rs982414、rs6679627、rs4786504、rs1799983、rs10984811、rs41417552、rs7677143、rs17777329、rs1008438、rs1061581、rs1043618、rs1042718、rs4963516、rs749174、rs10941679、rs275651、rs6089953、rs2297441、rs6713088、rs843752、rs12615793、rs12615793、rs11896604、rs10929728、rs1801282、rs3025030、rs12406290、rs28358587、rs4309、rs199983、rs480902、rs1008438、rs1965708、rs480902、rs479200、rs699、rs6194、rs516651、rs1799983、rs3025030、rs1799983、rs1799983、rs1004467、rs3813865、rs3025030、rs130293、rs28357093、rs2010963、rs1799983、rs1562453、rs11549465、rs12097901、rs2790859、rs186996510、rs8066114、rs4461142、rs1799983、rs4762、rs1799998、rs1799983、rs1799983、rs1801282、rs5931057、rs7473282、rs5927307、rs12655827、rs7770302、rs1991872、rs2397218、rs5974802、rs11581271、rs938355、rs7969849、rs2592121、rs10949682、rs6122447、rs7359910、rs16890905、rs2017869、rs6137010、rs1064134、rs13129566、rs4072318、rs10932688、rs6715605、rs1059524、rs6531084、rs12471246、rs12649142、rs17052028、rs7774693、rs2037632、rs13264220、rs12684453、rs4333695、rs12240999、rs5025116、rs3009568、rs7898954、rs4572038、rs7926263、rs1454014、rs3019644、rs9570755、rs4906864、rs4984295、rs5000698、rs6110226、rs6138362、rs2688172和rs5971167位点进行核酸质谱检测的PCR反应试剂、SAP反应试剂和延伸反应试剂。