[发明专利]基于毛干蛋白质组nsSNP进行人群来源推断的方法

摘要

本发明公开了基于毛干蛋白质组nsSNP进行人群来源推断的方法。本发明选取104个中国汉族样本和105个中国维吾尔族样本的毛干样本进行了毛干蛋白质组的提取，通过质谱检测毛干蛋白质组，筛选得到772个包含SAP的特异性多肽序列，对应703个SAP位点，并将所述SAP位点与千人基因组数据库中的SNP位点关联进而反推得到527个nsSNP位点组合。通过实验证明，本发明提供的nsSNP位点组合可用于非洲、东亚和欧洲三大人群推断。

主权项

1.用于区分非洲、东亚和欧洲三大人群的nsSNP位点组合；所述nsSNP位点组合由如下527个nsSNP位点组成：rs111433922、rs35340855、rs74058627、rs16829071、rs77912442、rs75073861、rs33931638、rs2274540、rs181507001、rs1340472、rs10776792、rs138286826、rs3790549、rs6587649、rs142660239、rs141677205、rs150525217、rs78489268、rs35492900、rs73004856、rs9793541、rs11205064、rs143680696、rs111350576、rs4329520、rs75424193、rs150172690、rs7527180、rs137886860、rs116208483、rs11544443、rs35358752、rs140222211、rs146608925、rs79957178、rs61743921、rs76446715、rs291102、rs3738046、rs2234697、rs35273824、rs55873785、rs61739198、rs147571909、rs61741026、rs3127679、rs61850830、rs61737718、rs41277978、rs11200927、rs144135625、rs2281878、rs150218827、rs149172507、rs3781409、rs142332607、rs146366062、rs77752215、rs114405390、rs117868609、rs78838117、rs73428416、rs147366020、rs61744476、rs115660558、rs112245148、rs74706151、rs1695、rs188029416、rs199773487、rs1945783、rs78786722、rs11604169、rs75068802、rs141425229、rs111738856、rs61750769、rs34495134、rs13312793、rs112319661、rs25680、rs35819349、rs1063193、rs114865992、rs76226247、rs74095220、rs4761786、rs2071588、rs202205489、rs79897879、rs183358379、rs140635030、rs2852464、rs61740813、rs112554450、rs61630004、rs1732301、rs36004911、rs61730587、rs2658658、rs1732263、rs61730589、rs1791634、rs61730590、rs148287450、rs2232387、rs142860834、rs138021918、rs11540301、rs17845411、rs201201647、rs148276250、rs11170177、rs35043606、rs76412202、rs74660757、rs2634041、rs636127、rs200729891、rs78374723、rs36143766、rs139252457、rs2638497、rs116117459、rs143673140、rs61743822、rs138008625、rs201904127、rs35645287、rs114939776、rs145486599、rs4964460、rs2723880、rs117037408、rs113902407、rs139495129、rs35201084、rs78872760、rs143710874、rs139160172、rs17111188、rs35926651、rs2229462、rs141486741、rs762063、rs10148371、rs11125、rs45560241、rs941920、rs61745465、rs45542736、rs59773088、rs116761065、rs7149578、rs151256890、rs55863440、rs77734634、rs11549015、rs142368943、rs76831919、rs149516006、rs147209733、rs6083、rs141566933、rs182752537、rs143921047、rs8040674、rs114486517、rs138510119、rs13226、rs61733465、rs2745101、rs7202502、rs26856、rs149302444、rs8063727、rs61734749、rs74444511、rs4850、rs143599196、rs61764619、rs149180816、rs139027672、rs115575792、rs35959859、rs11646443、rs115334480、rs142294143、rs111653425、rs8068049、rs140044904、rs33923045、rs139361222、rs2269859、rs7213256、rs112557906、rs112120285、rs17843023、rs17843021、rs142154718、rs721957、rs2010027、rs151267951、rs140634473、rs3829598、rs138200823、rs150218495、rs9635728、rs6503578、rs36006291、rs113142104、rs201968324、rs139615301、rs1497383、rs366700、rs34361798、rs61746658、rs444509、rs385055、rs111435962、rs428371、rs149778906、rs62067292、rs144662088、rs144085234、rs35424651、rs9894258、rs140430944、rs150620728、rs71373411、rs114488848、rs61741663、rs143499346、rs12450621、rs77779192、rs112544857、rs187425812、rs17737019、rs35371972、rs16966811、rs9916475、rs9916484、rs9916724、rs139509509、rs9893787、rs117083040、rs116901031、rs2604955、rs2071563、rs16966929、rs57682233、rs73983451、rs146792525、rs2071560、rs2071601、rs139209783、rs189378138、rs138303882、rs139838007、rs200825300、rs2301354、rs9675246、rs8082683、rs73294423、rs11551760、rs117484558、rs148173278、rs111383277、rs2229512、rs143043662、rs41283425、rs34891485、rs143967758、rs62636624、rs59657238、rs112984118、rs116700192、rs116640209、rs35074489、rs75138404、rs62621822、rs142608913、rs11871357、rs2228306、rs140743740、rs2853533、rs3737374、rs78014467、rs1455555、rs151208927、rs3746173、rs7250822、rs55862054、rs890850、rs10410943、rs80251258、rs2287813、rs62638750、rs117612375、rs150023166、rs10846、rs7249305、rs8111625、rs116923487、rs75291244、rs61731193、rs114254919、rs146740964、rs773902、rs12983721、rs61995739、rs61742630、rs151268424、rs112433506、rs2229259、rs148300955、rs185356090、rs116440799、rs143467587、rs191886465、rs189187210、rs114308190、rs4802741、rs144495841、rs73938668、rs116363585、rs115704323、rs57920974、rs533617、rs62130126、rs143205707、rs192390933、rs1109758、rs13413205、rs72937663、rs142729495、rs75630766、rs202041757、rs6761276、rs6743376、rs77686710、rs34355135、rs112797950、rs35852101、rs35830636、rs76148000、rs113701414、rs3815849、rs181520135、rs73996408、rs2233384、rs2233390、rs2233393、rs6431437、rs73102303、rs61732303、rs214814、rs114998364、rs34205880、rs111730906、rs145658539、rs6061066、rs3746609、rs17301126、rs41293138、rs200948404、rs17856024、rs2231619、rs61750835、rs36068952、rs78386672、rs45486695、rs61750208、rs2830585、rs141102396、rs113360916、rs3804010、rs61748317、rs16986753、rs73901140、rs113504861、rs151147550、rs117415039、rs115002444、rs74429119、rs79258920、rs16987932、rs78121368、rs61753641、rs76994627、rs181516402、rs233252、rs465279、rs111668637、rs411254、rs140821764、rs73909208、rs79740360、rs462007、rs78191358、rs78821735、rs73909210、rs34302939、rs61745911、rs7277175、rs201439546、rs115031369、rs61742280、rs112405400、rs133072、rs147348682、rs191014345、rs61730105、rs76321736、rs3796375、rs2228561、rs17080284、rs138055453、rs57006145、rs140995238、rs116174869、rs77141175、rs77299600、rs5955、rs144811342、rs61995956、rs186892593、rs115253144、rs17029215、rs3811813、rs10513155、rs76155491、rs73757391、rs147178651、rs148509798、rs77499935、rs181914313、rs149861653、rs35610885、rs150956127、rs146522449、rs2278371、rs61743236、rs6872614、rs145827614、rs77767937、rs112465391、rs77758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