本申请公开了靶向STAT3蛋白Ser701磷酸化的抗原肽及其应用。该抗原肽具有与SEQ ID NO.1~4所示的氨基酸序列、或与该序列具有相同功能的同源序列。应用该抗原肽制备的抗体能检测出细胞和组织中的STAT3蛋白Ser701磷酸化水平,有助于研究STAT3蛋白Ser701磷酸化的分子机制和生物学功能;为研究STAT3在细胞周期进展、自噬、凋亡、代谢、炎症本申请中提供了一种STAT3蛋白Ser701磷酸化抗体的制备方法,该方法操作简单,通过此方法制得的抗体特异性强、纯度高、稳定性好。
Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ala Phe SerSer Tyr Ala Met Gly Trp Tyr Arg Gln Ala ProGly Lys Glu Cys Glu Leu Val Ala Thr Ile Thr Ser Ala Gly Gly Ser Thr Asn Tyr Ala Asp Ser Val Lys GlyArg Phe Thr Leu Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr AlaGlu Tyr Tyr Cys Asn Ala Glu SerSer Thr Thr Gly Trp Gly Thr Ile Cys Asp Ala Leu Asp Ala Phe Gly GlnGly Thr Gln Val Thr Val SerSer。
本发明公开一种多肽、CD19单域抗体、核苷酸序列及试剂盒,其中,该多肽包括4个框架区和3个可变区,该多肽序列如下:Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Ile Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ile Ser Tyr Asp Met Asn Trp Leu Arg Gln Thr Pro Gly Lys Gly Pro Glu Trp Val Ser Gly Ile Asn Thr Gly Gly Ser Arg Thr Tyr Tyr Ala Asp Ser Val Lys Asp Arg Phe Thr Val Ser Arg Tyr Asn Ala Lys Asn Thr Leu Tyr Leu Gln Met Asp Ser Leu Lys ProGln Gly Thr Gln Val Thr Val SerSer。
本发明公开一种多肽、IL17A/F单域抗体、核苷酸序列及试剂盒,其中,该多肽序列如下:Asp Val Gln Leu Gln Ala Ser Gly Gly Gly Leu Val Gln Pro GlyGly Ser Leu Arg Leu Ser Cys Val Ala Pro Gly Asn Ile Phe Ser Asp Asn Ala Met Gly Trp Tyr Arg Gln AlaPro Gly Lys Gln Arg Glu Phe Val Ala His Ile Thr Thr Arg Ser Gly Ala Gly Tyr Val Asp Ser Val Lys Gly ArgPhe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr AlaVal Tyr Tyr Cys Asn Thr Asn Pro Pro Met Trp Thr Tyr Trp Gly Gln Gly Thr Gln Val Thr Val SerSer。
本发明公开一种B7H4/1E10单克隆抗体及其应用,该抗体的轻链可变区的3个互补决定区序列分别为:Lys Ser Val Ser Thr Ser Gly Tyr Ser Tyr;Leu Val Ser;Gln His Ile Arg Glu Leu Thr Arg;重链可变区的3个互补决定区序列分别为:Gly Phe Ser Leu Thr Ser Tyr Gly;Ile Trp Ala Gly GlySer Thr;Ala Arg Glu Arg Ala Arg Leu Leu Arg Ile Asn Ala Met Asp Tyr。