[发明专利]头孢菌素晶体及其制备方法

摘要

本发明的目的在于提供一种在经济贮存条件下长期极其稳定的头孢菌素晶体。本发明的该头孢菌素晶体可通过使油状的头孢菌素在含醇溶剂中结晶而获得。

主权项

1.由下式所代表的头孢菌素晶体，其中R为对甲氧基苄基或二苯基甲基，当R代表对甲氧基苄基时，该晶体具有下列X-射线粉末衍射图谱，该图谱由λ＝1.5418的铜射线穿过单色仪丝滤器而获得的：?????d????????????????????????????????????????????I/Io12.94-12.96????????????????????????????????????0.55-0.6711.67-11.69????????????????????????????????????0.46-0.56?9.90-?9.92????????????????????????????????????0.09-0.11?6.46-?6.48????????????????????????????????????0.57-0.69?6.32-?6.34????????????????????????????????????0.22-0.26?5.80-?5.82????????????????????????????????????0.56-0.68?4.95-?4.97????????????????????????????????????0.42-0.52?4.72-?4.74????????????????????????????????????0.63-0.77?4.65-?4.67????????????????????????????????????0.65-0.79?4.50-?4.52????????????????????????????????????0.60-0.74??4.43-4.45????????????????????????????????????????0.28-0.34??4.28-4.30????????????????????????????????????????0.50-0.62??4.16-4.18??????????????????????????????????????????1.00??4.04-4.06????????????????????????????????????????0.23-0.28??3.97-3.99????????????????????????????????????????0.15-0.19??3.85-3.87????????????????????????????????????????0.67-0.81??3.77-3.79????????????????????????????????????????0.42-0.52??3.69-3.71????????????????????????????????????????0.13-0.15??3.55-3.57????????????????????????????????????????0.06-0.08??3.53-3.54????????????????????????????????????????0.05-0.07??3.44-3.46????????????????????????????????????????0.49-0.59??3.36-3.38????????????????????????????????????????0.18-0.22??3.28-3.30????????????????????????????????????????0.13-0.15??3.21-3.23????????????????????????????????????????0.18-0.22??3.19-3.21????????????????????????????????????????0.14-0.17??3.15-3.17????????????????????????????????????????0.18-0.22??3.08-3.10????????????????????????????????????????0.16-0.20??2.89-2.91????????????????????????????????????????0.20-0.24??2.84-2.86????????????????????????????????????????0.09-0.11??2.67-2.69????????????????????????????????????????0.13-0.15??2.59-2.61????????????????????????????????????????0.14-0.18??2.57-2.59????????????????????????????????????????0.10-0.12??2.49-2.51????????????????????????????????????????0.09-0.11??2.48-2.50????????????????????????????????????????0.12-0.14当R代表二苯基甲基时，该晶体具有下列X-射线粉末衍射图谱，该图谱由λ＝1.5418的铜射线穿过单色仪丝滤器而获得的：?????d????????????????????????????????????????????I/Io14.86-14.88??????????????????????????????????????1.0013.45-13.47????????????????????????????????????0.49-0.59?8.67-?8.69????????????????????????????????????0.09-0.11?8.44-?8.46????????????????????????????????????0.09-0.11?8.01-?8.03????????????????????????????????????0.10-0.12?7.75-?7.77????????????????????????????????????0.28-0.34?7.07-?7.09????????????????????????????????????0.32-0.39?6.75-?6.77????????????????????????????????????0.23-0.28?5.88-?5.90????????????????????????????????????0.11-0.13?5.59-?5.61????????????????????????????????????0.84-0.99?5.44-?5.46????????????????????????????????????0.30-0.36?5.30-?5.32????????????????????????????????????0.48-0.58?5.03-?5.05????????????????????????????????????0.59-0.72?4.96-?4.98????????????????????????????????????0.18-0.22?4.86-?4.88????????????????????????????????????0.50-0.62?4.74-?4.76????????????????????????????????????0.62-0.76?4.63-?4.65????????????????????????????????????0.32-0.39?4.58-?4.60????????????????????????????????????0.40-0.48?4.47-?4.49????????????????????????????????????0.39-0.47?4.42-?4.44????????????????????????????????????0.54-0.66????4.34-4.36?????????????????????????????????0.27-0.33????4.20-4.22?????????????????????????????????0.70-0.86????4.15-4.17?????????????????????????????????0.35-0.43????4.09-4.11?????????????????????????????????0.48-0.58????3.93-3.95?????????????????????????????????0.86-0.99????3.74-3.76?????????????????????????????????0.34-0.42????3.69-3.71?????????????????????????????????0.54-0.66????3.65-3.67?????????????????????????????????0.20-0.24????3.62-3.64?????????????????????????????????0.14-0.18????3.73-3.75?????????????????????????????????0.20-0.24????3.52-3.54?????????????????????????????????0.35-0.43????3.45-3.47?????????????????????????????????0.44-0.54????3.38-3.40?????????????????????????????????0.23-0.28????3.31-3.33?????????????????????????????????0.19-0.23????3.24-3.26?????????????????????????????????0.14-0.17????3.22-3.24?????????????????????????????????0.27-0.33????3.20-3.22?????????????????????????????????0.36-0.44????3.11-3.13?????????????????????????????????0.14-0.17????3.05-3.07?????????????????????????????????0.22-0.26????2.92-2.94?????????????????????????????????0.10-0.12????2.89-2.91?????????????????????????????????0.12-0.14????2.79-2.81?????????????????????????????????0.22-0.26????2.68-2.70?????????????????????????????????0.19-0.23其中d为晶面间距，I/I0为相对强度。