[发明专利]一种用于预测子痫前期风险的基因组合、子痫前期风险预测模型及其构建方法

权利要求书

1.一种构建子痫前期风险预测模型的装置，其特征在于，包括：

数据预处理模块，将所获得的499个易感基因与46个临床检测数据转换成数字特征向量，用数字特征向量表示每一例样本，对每一例样本数据标注其患病情况；

模型构建模块，根据随机森林算法的模型构建规则，对样本所对应的数字特征向量进行模型构建，生成一个包含1000棵决策树的随机森林模型；

模型误差率计算模块，随机森林在生成每颗决策树时随机且有放回地抽取样本，每棵决策树有1/3的样本未抽取到，这1/3未抽取到的样本是每棵决策树的袋外错误率样本，将这1/3未抽取到的样本作为测试集来计算随机森林模型的误差率；

所述499个易感基因分别为：rs1111875、rs3764650、rs890293、rs4934、rs2230806、rs405509、rs12983082、rs2516049、rs10830963、rs2000813、rs7202116、rs3764261、rs7079、rs1805094、rs8178847、rs1421811、rs715987、rs8096897、rs574957、rs10744835、rs1991391、rs7977406、rs11066188、rs2036914、rs8099917、rs12979860、rs10048158、rs1801689、rs9264942、rs9277535、rs2523393、rs2230204、rs7107152、rs12086634、rs1242229、rs2236242、rs3779512、rs1864163、rs1549758、rs5491、rs7578597、rs7209395、rs6042935、rs121912702、rs155524、rs7640747、rs7926335、rs743395、rs1800206、rs11977526、rs3804099、rs1799750、rs1049337、rs28362491、rs10120688、rs1051740、rs2167270、rs7804372、rs11568821、rs12203592、rs1799724、rs1805192、rs2066847、rs1800451、rs5030737、rs4766578、rs4149056、rs4675378、rs281874770、rs4321325、rs11018628、rs1800794、rs1805010、rs780093、rs3853839、rs7805969、rs7574865、rs8178822、rs333、rs2384550、rs925489、rs57659670、rs853326、rs180223、rs1472565、rs2596623、rs231779、rs4850755、rs6885099、rs1800693、rs2046045、rs4704397、rs1137617、rs10733113、rs653178、rs10774625、rs2517532、rs9910950、rs8178848、rs16950081、rs4925295、rs963167、rs2647528、rs2319125、rs4581、rs2288493、rs79154414、rs2277698、rs2279744、rs2217332、rs8178819、rs6906021、rs2736340、rs4915077、rs1523127、rs1554973、rs17145713、rs1041981、rs11538264、rs204999、rs2476601、rs6457452、rs9277534、rs3099844、rs4149584、rs492899、rs17630235、rs9322331、rs556442、rs3890182、rs10938397、rs4773724、rs1275988、rs1558902、rs1800437、rs17577、rs13385、rs2074311、rs642858、rs11651270、rs2237895、rs231840、rs1799999、rs2292239、rs7163757、rs2670660、rs11066280、rs7178572、rs4721、rs391300、rs4828038、rs7713645、rs3087243、rs17817449、rs455060、rs2075290、rs13702、rs3021094、rs1260326、rs2237892、rs1550805、rs6259、rs2083637、rs2779248、rs1137933、rs3847987、rs77060950、rs7709243、rs7770619、rs1801278、rs7903146、rs4506565、rs17681684、rs17696736、rs1050828、rs231357、rs199972616、rs4416547、rs10509305、rs12762303、rs2280275、rs2014408、rs1532624、rs3746429、rs1926723、rs11105354、rs7439293、rs445925、rs3850641、rs7194256、rs867186、rs3184504、rs5743293、rs825476、rs7580658、rs1801693、rs854560、rs1056917、rs61996318、rs9898、rs13146272、rs4311994、rs1654433、rs11105357、rs4148189、rs4576240、rs11751198、rs11968400、rs11970154、rs12210887、rs13118、rs2075015、rs2285321、rs2394392、rs2508015、rs2523995、rs2524272、rs25527、rs28986465、rs29243、rs3130663、rs3130685、rs3132584、rs64036、rs6457254、rs6924270、rs6933400、rs6937357、rs73055442、rs7749235、rs9261800、rs9267547、rs9468805、rs9500864、rs1441756、rs15285、rs9941065、rs2596574、rs11085421、rs3785617、rs78010183、rs2292354、rs289717、rs247616、rs879922、rs1799945、rs2097055、rs662、rs1532085、rs3757354、rs3813082、rs326、rs662799、rs12597002、rs4131229、rs964184、rs13105517、rs1260333、rs2075291、rs5104、rs670、rs17482753、rs2043085、rs4969168、rs7350481、rs12678919、rs6671879、rs4743771、rs328、rs285、rs6720173、rs10096633、rs301、rs1003723、rs2303790、rs2266788、rs429358、rs10503669、rs1051931、rs7756935、rs10790162、rs5174、rs562556、rs4253728、rs2269702、rs66698963、rs9326246、rs7016880、rs1801394、rs1805087、rs9852991、rs12230074、rs9815354、rs6768438、rs957525、rs9816772、rs11024074、rs10506974、rs3754777、rs1173771、rs13394970、rs17249754、rs176185、rs2070759、rs6410、rs11105378、rs2586886、rs2004776、rs11191548、rs35444、rs6433027、rs3749585、rs16998073、rs1378942、rs2681492、rs6495122、rs12413409、rs7726475、rs5049、rs1401982、rs1105378、rs16948048、rs11014166、rs11568020、rs381815、rs11065987、rs1131882、rs11572325、rs880315、rs4612666、rs651007、rs671、rs10507391、rs3135506、rs10743565、rs1426409、rs193921036、rs200898934、rs201223301、rs374976508、rs7080、rs2237076、rs3765407、rs3820059、rs9831647、rs1862176、rs9939609、rs9638978、rs9393931、rs9381475、rs9380142、rs9340799、rs927332、rs909253、rs846910、rs843010、rs842991、rs836135、rs836132、rs821466、rs7963771、rs7943316、rs763780、rs7579169、rs7571613、rs7564968、rs7412、rs732609、rs699947、rs699、rs698090、rs6802220、rs661348、rs6594013、rs6550005、rs6489992、rs6478974、rs6269、rs6025、rs56124946、rs5442、rs5051、rs4842666、rs4818、rs479200、rs4784744、rs4769613、rs4762、rs4633、rs4289236、rs4150196、rs3918227、rs3905000、rs3819526、rs3812475、rs3803012、rs3801266、rs3783550、rs3773663、rs3773640、rs3761548、rs3735481、rs366510、rs35821928、rs3025039、rs2954033、rs2854371、rs284277、rs2681472、rs266729、rs2638953、rs261334、rs2596622、rs25648、rs2549782、rs233115、rs2322659、rs231775、rs2297518、rs2287848、rs2287845、rs2275913、rs2271037、rs2241766、rs2236852、rs2236711、rs2234693、rs2232365、rs2230820、rs222133、rs2200733、rs2161983、rs2074611、rs2070744、rs2059806、rs2010963、rs1991515、rs193741、rs1884082、rs1805388、rs1805017、rs1801133、rs1801131、rs1800896、rs1800872、rs1800629、rs1800469、rs1800450、rs1799983、rs1799963、rs1799889、rs17783344、rs17686866、rs1710、rs16972197、rs16972194、rs1695、rs16846876、rs1610696、rs1570360、rs1501299、rs1424954、rs1358340、rs13429458、rs1341667、rs13405728、rs13401889、rs1319501、rs12831006、rs12711941、rs12707079、rs12579302、rs12150550、rs12150220、rs1205、rs12035521、rs11895934、rs11792480、rs11646213、rs1155708、rs115015150、rs1143627、rs1130409、rs11209026、rs11190179、rs11129420、rs11105368、rs11105364、rs11105328、rs111033530、rs10898392、rs10889677、rs10811661、rs10739778、rs1063320、rs1014064、rs10121110、rs1010、rs1004467。