[发明专利]基于基因多态性指导儿童患者精准用药的试剂盒、应用和方法

摘要

本发明公开了基于基因多态性指导儿童患者精准用药的试剂盒、应用和方法。方法是选择不同的基因检测试剂盒，检测CYP1A2、CYP2B6、CYP2C8、CYP2C19、CYP2C9、CYP2D6、CYP2E1以CYP3A4遗传多态性。

主权项

如下基因多态性在制备指导儿童患者精准用药试剂盒中的应用：(1)CYP1A2：包含rs11636419、rs12720461、rs2069514、rs2069522、rs2069526、rs2470890、rs2472299、rs2472300、rs2472304、rs28399424、rs35694136、rs3743484、rs45564134、rs4646425、rs4646427、rs55889066、rs56276455、rs762551、rs72547516、rs72547517、rs72547513、rs72547511、rs72547515多态性中的一个或多个组合或单倍型；(2)CYP2B6：包含rs10403955、rs1042389、rs12721646、rs12721655、rs139801276、rs186335453、rs2054675、rs2279343、rs2279344、rs2279345、rs281864907、rs28399499、rs3211371、rs34097093、rs34223104、rs35303484、rs35979566、rs36118214、rs36079186、rs371424910、rs373489637、rs3745274、rs3786547、rs45482602、rs4802101、rs4802104、rs4803419、rs58425034、rs707265、rs7254579、rs7260329、rs8109848、rs8192709、rs8192719多态性中的一个或多个组合或单倍型的基因；(3)CYP2C8：包含rs10509681、rs1058930、rs1058932、rs1113129、rs11572076、rs11572080、rs11572103、rs11572177、rs1341162、rs1341164、rs17110453、rs193451、rs1934951、rs1934953、rs1934980、rs2071426、rs2275622、rs3832694、rs66501115、rs7909236多态性中的一个或多个组合或单倍型；(4)CYP2C19：包含rs11188072、rs12248560、rs12767583、rs12768009、rs12769205、rs12773342、rs145119820、rs17878459、rs17879685、rs17882687、rs17884712、rs28399504、rs3758581、rs3814637、rs41291556、rs4244285、rs4917623、rs4986893、rs4986894、rs55640102、rs55752064、rs55948420、rs56337013、rs57081121、rs5787121、rs58973490、rs6413438、rs6583954、rs72552267、rs72558184、rs72558185、rs72558186多态性中的一个或多个组合或单倍型；(5)CYP2C9：包含rs10509680、rs1057909、rs1057910、rs1057911、rs12572351、rs12782374、rs141011391、rs17847042、rs1799853、rs1934963、rs1934967、rs1934968、rs1934969、rs2017319、rs2256871、rs28371685、rs28371686、rs2860905、rs4086116、rs4917639、rs4918758、rs56165452、rs67807361、rs7089580、rs71486745、rs72558187、rs72558188、rs72558189、rs72558190、rs72558191、rs7900194、rs9332094、rs9332096、rs9332104、rs9332120、rs9332127、rs9332130、rs9332131、rs9332146、rs9332174、rs9332197、rs9332238、rs9332239多态性中的一个或多个组合或单倍型；(6)CYP2D6：包含rs1065852、rs1080983、rs1080985、rs1080989、rs1135840、rs1135824、rs138417770、rs16947、rs28360521、rs28371706、rs28371725、rs28371733、rs35742686、rs367543000、rs371793722、rs3892097、rs5030655、rs5030656、rs5030862、rs5030863、rs5030865、rs5030867、rs567606867、rs59421388、rs61736512、rs72549354、rs745746329、rs74966855、rs750996195、rs76088846、rs777560972多态性中的一个或多个组合或单倍型；(7)CYP2E1：包含rs1329149、rs2031920、rs2070672、rs2070673、rs2070676、rs2249694、rs2249695、rs2480256、rs2515641、rs2515644、rs3813865、rs3813867、rs4646976、rs55897648、rs6413419、rs6413420、rs6413432、rs72559710、rs743535、rs8192772、rs8192775、rs8192766、rs8192780、rs915906、rs915908、rs915909多态性中的一个或多个组合或单倍型；(8)CYP3A4：包含rs1041988、rs12333983、rs12721627、rs12721629、rs12721634、rs1851426、rs2242480、rs2246709、rs2687116、rs2740574、rs28371759、rs3091339、rs3208361、rs3208363、rs35599367、rs3735451、rs45614732、rs4646437、rs4646438、rs4646440、rs4986907、rs4986908、rs4986909、rs4986910、rs4986913、rs4986914、rs4987161、rs55785340、rs55901263、rs55951658、rs56324128、rs67666821、rs67784355、rs6956344、rs72552799多态性中的一个或多个组合或单倍型。